Development of Risperidone PLGA Microspheres
نویسندگان
چکیده
منابع مشابه
Development of Risperidone PLGA Microspheres
The aim of this study was to design and evaluate biodegradable PLGA microspheres for sustained delivery of Risperidone, with an eventual goal of avoiding combination therapy for the treatment of schizophrenia. Two PLGA copolymers (50 : 50 and 75 : 25) were used to prepare four microsphere formulations of Risperidone. The microspheres were characterized by several in vitro techniques. In vivo st...
متن کاملSurface modification of PLGA microspheres.
Microspheres made of poly(lactic-co-glycolic acid) (PLGA) are biocompatible and biodegradable, rendering them a promising tool in the context of drug delivery. However, nonspecific adsorption of plasma proteins on PLGA micro- and nanospheres is a main limitation of drug targeting. Poly(L-lysine)-g-poly(ethylene glycol) (PLL-g-PEG), physisorbed on flat metal oxide surfaces, has previously been s...
متن کاملIVIVC of parenteral PLGA microspheres
There have been only a dozen parenteral extended release formulations that are designed to deliver drugs from a week up to 6 months since the first introduction of Lupron Depot® made of poly(lactic-coglycolic acid) (PLGA) microspheres in 1989. All parenteral extended release formulations are made of PLGA in the form of microspheres, solid implants, and in situ forming implants. Over the past fe...
متن کاملPLGA Microspheres Incorporated Gelatin Scaffold: Microspheres Modulate Scaffold Properties
Freeze drying is one of the popular methods of fabrication for poly(lactide-co-glycolide) (PLGA) microspheres incorporated polymer scaffolds. However, the consequence of microspheres incorporation on physical and biological properties of scaffold has not been studied yet. In this study, attempt has been made to characterize the effect of PLGA microsphere incorporation on the physical properties...
متن کاملElectrospray synthesis of PLGA TIPS microspheres
Department of Electronic & Electrical Engineering, University College London, Torrington Place, WC1E 7JE, London, United Kingdom School of Chemical Engineering, University of Birmingham, B15 2TT, Birmingham, United Kingdom Department of Mechanical Engineering & Materials Science, Yale University, New Haven, CT, 06520-8286, USA Division of Medicine, University College London, 21 University Stree...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Drug Delivery
سال: 2014
ISSN: 2090-3014,2090-3022
DOI: 10.1155/2014/620464